In brief

Psoriasis, atopic dermatitis and seborrhoeic dermatitis are associated with lower zinc levels. Intervention data remain limited and do not establish a clinical benefit from routine supplementation.

Zinc status in dermatoses

Lower zinc levels and supplementation efficacy are separate questions in skin-health research, each requiring its own evidence. Published on 5 October in Nutrition Reviews, this systematic review and meta-analysis includes 13 studies of psoriasis, atopic dermatitis and seborrhoeic dermatitis. The synthesis identifies associations between these conditions and zinc status.

The evidence on supplementation

Differences in study populations, measurement methods and biological samples affect interpretation. Intervention data are also limited: the evidence does not establish a clinical benefit from routine zinc supplementation alongside standard care. Finding a lower biomarker level therefore leaves the question of treatment efficacy open.

Implications for formulation research

For skin-health product developers, assessment starts with the intended population. Meeting nutritional requirements, correcting a documented deficiency and improving a skin outcome need specific evaluation. Baseline nutritional status and concurrent treatments form part of that work and help define which conclusions can be applied to a formulation.

Why it matters

For skin-health formulations, baseline nutritional status, deficiency correction and clinical outcomes each require specific supporting evidence.

Evidence limit

Studies differ in populations, measurement methods and biological samples. An association with lower levels does not itself establish supplementation efficacy.

Editorial note. This content is intended for industry professionals. It does not constitute medical advice, therapeutic guidance or regulatory advice. Read our editorial method.

Read the original source · Nutrition Reviews